Reminds me of two mangas I've seen that got published in magazines a few years back.
A ) A toilet-obsessed MC Isekai'ed with toilet powers. It's a comedy, but the poop jokes ain't just flinging poops all over and was played straight, even informative sometimes. And the storyline did work with it quite well.
It got to the end and had books printed, and was pretty decent.
B ) An MC got Isekai'ed, and that Isekai's DIRTY. Basically it's all-age piss & scat where you laughed at how "realistic" it was.
I don't think it got to have a 2nd chapter? Stumbled upon it in Pixiv again and there the artist just "let-go" so to speak.
See what you did there? v=3=v